Transient lingual papillitis.

A case of recurrent, clinically innocuous, but painful papules involving the tongue dorsum of a 25-year-old man is presented. The lesions were interpreted to represent a transient lingual papillitis. This a poorly understood, but benign and self-limited condition involving the tongue fungiform papillae, which does not appear to be widely recognized.

Bone Marrow-derived Cell Therapy for Oral Mucosal Repair after Irradiation.

Oral mucositis (ulcer) is a serious and painful side effect for patients with head and neck cancer following radiation therapy. However, current clinical strategies cannot efficiently prevent the occurrence of oral mucositis. In this study, we investigated whether bone marrow-derived cells (BMDCs) prevented the occurrence and/or decreased the severity of radiation-induced oral mucositis. Fresh concentrated BMDCs from male C3H mice were transplanted intravenously into female mice after tongue irradiation. For 14 days postirradiation, the changes of body weight and the time courses of ulceration were observed. Until the ulcer reached maximum size (7 days postirradiation), macroscopic and histologic analyses of harvested tongues were performed to detect the behavior of donor BMDCs. Between 2 and 5 days postirradiation, BMDCs-transplanted mice showed more expression of stem cell markers (c-Kit, Sca-1) and EGFR and fewer apoptotic cells when compared with nontransplanted control mice (irradiation group). On day 7, there were fewer and smaller ulcers observed in the BMDCs-transplanted group. Tongues of these mice had preserved their epithelial thickness, and regenerative activities (blood vessels formation, cell proliferation) were higher than they were in the irradiation group. Fluorescently labeled BMDCs were not detected in tongue epithelium but rather in connective tissue (dermis) just below the basal cell layer. These findings suggest that exogenous BMDCs behave to reduce radiogenic oral mucositis in a paracrine manner.

[Integrated approach to the treatment of oral mucosa diseases in patients with chronic gastritis].

The article presents data on the clinical and microbiological short and long term efficacy of treatment of the oral mucosa diseases in patients with Helicobacter pylori associated and not associated chronic gastritis depending on the chosen treatment regimen.

Glositis romboidal media: revisión a propósito de un caso clínico / glossitis Rhomboid average: review of a clinical case

La glositis romboidal media (GRM) es una alteración benigna, poco frecuente, que afecta ligeramente más a los varones. Suele localizarse en la línea media del dorso de la lengua por delante de la “V” lingual, en forma de área rojiza, romboidal, de superficie plana, como una mácula o a veces exofítica, mamelonada, que puede sobresalir de 2 a 5 mm y en la que no se observan papilas filiformes. Se presenta el caso clínico de un varón de 50 años de edad que consulta por presentar una lesión en dorso de lengua, situada en la línea media.

Median rhomboid glossitis (MRG) is an uncommon benign abnormality of the tongue, most frequently affecting men. It is typically located around the midline of the dorsum of the tongue, anterior to the lingual “V”, appearing as a reddish, rhomboid area, depapillated, flat maculate or mamillated and raised by2- 5 mm. This paper reports a case of rhomboid glossitis in a 50-year-old man who consulted for a lesion on the dorsum of the tongue, in a medial location.

Glossal abscess as a complication of tongue-base suspension surgery.

Approximately 60 cases of tongue abscess have been reported in the English-language literature over the past 30 years. We report what we believe is the first case of a glossal abscess that arose as a complication of tongue-base suspension surgery. The patient was a 31-year-old man who presented with a several-day history of odynophagia, tongue swelling, voice changes, and increased snoring. Two years earlier, he had undergone a tongue-base suspension procedure for the treatment of obstructive sleep apnea. Computed tomography (CT) revealed a tongue abscess. During peroral incision and drainage, a knotted 0 Prolene suture was discovered within the abscess cavity. The suture was removed, the area was thoroughly irrigated, the drain was placed in the abscess cavity, and the incision was loosely closed. On postoperative day 5, repeat CT revealed resolution of the abscess, and the patient was discharged on oral antibiotics. Although glossal abscess is very rare, physicians should consider it in the differential diagnosis of any patient who presents with lingual swelling following tongue-base suspension surgery.

Neonatal lingual and gastrointestinal mucormycosis in a case of low anorectal malformation-a rare presentation.

We report a 1.7 kg male infant with a low anorectal malformation treated at an outside facility and referred to us on postoperative day 11. At presentation, his upper abdomen was distended, and he had perianal mucoid discharge. The tongue had a blackish discoloration. An erect abdominal radiograph showed a few fluid-filled bowel loops in the upper abdomen with a gasless lower abdomen and pelvis, suggestive of upper small bowel obstruction. There were no specific radiological features of necrotizing enterocolitis. He underwent laparotomy and bowel resection for perforated jejunum. Histopathology of the tissue specimen was suggestive of mucormycosis. Postoperatively, he received intravenous amphotericin B (liposomal) and was started on liquid enteral nutrition after 2 weeks. However, the anterior two thirds of his tongue gradually sloughed off. He is awaiting reconstruction of the tongue. The purpose of this report is to emphasize that physicians should have a high index of suspicion for oral and gastrointestinal tract mucormycosis in neonates with metabolic disturbances who present with a discolored oral mucosa and an abdominal mass with intestinal obstruction. Early diagnosis and an aggressive approach of combined medical and surgical treatment may improve the outcome of patients with this potentially lethal invasive disease.

Glositis herpética necrosante / Necrotizing herpetic glossitis

Se recibe paciente de 8 años de edad, con un peso de 18 Kg. siendo delgada en complexión, Con problema para poder comer, con adenopatía grado 4 en ambos submaxilares, sin poder hablar, y gesticular y con dificultad dolorosa para poder deglutir, (odinofagia), con fiebre de 39 grados, cefalea en parietales, y muy sensible a la patología de su problema.

Glositis herpética necrosante / Necrotizing herpetic glossitis

Se recibe paciente de 8 años de edad, con un peso de 18 Kg. siendo delgada en complexión, Con problema para poder comer, con adenopatía grado 4 en ambos submaxilares, sin poder hablar, y gesticular y con dificultad dolorosa para poder deglutir, (odinofagia), con fiebre de 39 grados, cefalea en parietales, y muy sensible a la patología de su problema.

Treatment of smarting symptoms in the oral mucosa by appliance of lingual acrylic splints.

UNLABELLED: The aim of the present study was to evaluate the relieving effect on smarting symptoms in the oral mucosa by the use of lingual acrylic splints. Recruited for the study were 53 persons, 48 women and 5 men, with smarting symptoms in the oral mucosa, not associated with general disease, and with signs of erythema, most often on the apex of the tongue, and/or crenated tongue. Symptoms were registered from the tongue in 49 cases, the palate in 28 cases and the lips in 15 cases. A lingual acrylic splint was applied in the lower jaw behind the front teeth, not covering the occlusal surfaces and it was kept in the mouth day and night. At an average the splint was used in 8 months. A group of 10 women was recruited for comparison. These women were just instructed to avoid tongue pressing for at least a two month period. All patients were asked whether the treatment affected the symptoms and they registered their opinion on a 100 mm VAS line with end effect points "not helped at all/deteriorated" and "now completely without symptoms". On the question whether the treatment had affected the symptoms, the average result was 55 mm and median value 64 mm. The treatment results were somewhat better among those with moderate initial symptoms compared to those with severe symptoms. Interestingly, in the group for comparison, symptom VAS values improved significantly from 60 to 41 mm (P < 0.05). CONCLUSION: Treatment of smarting symptoms in the oral mucosa may to a great extent be relieved by the application of an acrylic lingual splint. However, before using this splint method, an effort should be made to make the patient actively avoid tongue pressure.

Case report: the importance of oral manifestations in diagnosing iron deficiency in childhood.

AIM: The aim of this article is to report a case of iron deficiency diagnosed in a child after routine oral examination. CASE REPORT: A 5-year-old male child of African descent was brought to the paediatric dental clinic of a public university in Rio de Janeiro, Brazil. His mother's main complaint was her child's decayed teeth and sensitivity in the tongue every time he ate spicy or hot food. Anamnesis revealed chronic respiratory problems due to allergy, two previous episodes of anaemia and hospitalization about 15 months before the dental visit because of severe primary herpetic gingivostomatitis. Soft tissue examination revealed his tongue had various patches of atrophic mucosa characterizing absence of papillae in these areas. The child's dietary assessment indicated that he never ate meat or vegetables. Haematological investigation showed that the child probably had an iron deficiency, although the full blood count was not totally compatible with anaemia. A rapid initial recovery was quite noticeable after the beginning of oral therapy with ferrous sulphate, as remission of tongue sensitivity as well as papillae neoformation were observed.

[Burning mouth syndrome--etiology, differentialdiagnostical aspects and therapy]. / Das Burning Mouth Syndrom--Ursachen, Differentialdiagnose und Therapie.

Burning Mouth Syndrome (BMS) or glossodynia is a chronic pain syndrome that mainly affects middle-aged/elderly women. This condition is probably of multifactorial origin, often idiopathic, and its etiopathogenesis remains largely enigmatic. Visible pathologic lesions of the oral mucosa or processes are usually not evident. Etiologic factors that have been reported include several disorders (e. g. hematologic disorders, denture factors, the climacteric, infections, endocrinological, neurological or psychiatric disorders). On the other hand psychological factors, such as anxiety, depression and phobias have been reported to play a significant role at the beginning of this nosological entity. BMS related to nutritional deficiency is uncommon. A systemic approach to assessment is essential and the opinion of other specialities, particularly internal medicine, dentistry or neurology, may be of help. Treatment is of the underlying cause but in many cases no specific aetiological factor is identified. Non-indicated substitution therapy of suspected but unproved deficiency states must be avoided. Treatment approaches were divided into topical and systemic strategies. However, there is little research evidence that provides clear guidance for those treating patients with BMS.

Glossitis and other tongue disorders.

Patients frequently present complaining of tongue abnormalities. Knowledge of normal tongue anaomy an d architecture enable the clinician t odifferentiate variations of normal from abnormal conditions. Many tongue conditions are benign and. require reassurance and explanation, with little to no treatment. Others can signify systemic disorders. Examination of the tongue is an integral part of a complete physical examination. Recognizing the disorders of the tongue that are benign and do not require treatment or further evaluation prevents unnecessary testing for the patient. Careful evaluation of the tongue may provide valuable clues to a systemic disorder.

Lesiones estomatológicas desde el nacimiento hasta los tres años / Oral lesions from birth to three years of age

Con el propósito de que el odontólogo que atiende niños pueda comprender y retener las distintas características de las lesiones, hemos dividido este trabajo en dos períodos distintos de su desarrollo físico. Todo lo expuesto aquí es un resumen de 30 años de trabajo junto a odontólogos y médicos que dirigen las distintas especialidades afines a la estomatología pediátrica. Este período lo hemos dividido en dos partes: Primera parte a) Lesiones que afectan al niño desde el nacimiento hasta los doce meses de vida. Quistes de Queratina (Nódulos de Bohn, Perlas de Epstein y quistes de la lámina dental). b) Lesiones névicas-angiomas y lesiones pigmentarias. Segunda parte: Nos hemos dedicado a las manifestaciones de las enfermedades producidas por virus, hongos y bacterias. Queremos alcarar que estas lesiones pueden aparecer en otra etapa de la vida del niño. Al final de la segunda parte mencionamos lesiones propias de los labios (queilitis) y de la lengua (glositis) (AU)

Serious complication of tongue piercing.

The case of an 18-year-old patient who developed critical upper airway compromise after central tongue piercing is presented. Otolaryngologists must be aware of the many potential complications of tongue piercing and their management.

Oral allergy syndrome successfully treated with pollen immunotherapy.

BACKGROUND: Some patients with allergic rhinitis have oral allergic reactions to fresh fruits and vegetables. This phenomenon has been termed "oral allergy syndrome" and is proposed to be due to cross-reacting allergens in the foods and pollens. METHODS: We report a patient with allergic rhinitis and oral allergy syndrome treated with pollen immunotherapy. Prior to immunotherapy, eating any fresh fruit or vegetable caused immediate itching and swelling of his tongue and throat. Prick skin test titration with pollens and foods was performed before and after 13 months of immunotherapy. Specific IgE immunoassay was performed with the same extracts on serum obtained before and after 7 and 13 months of immunotherapy. IgE immunoblots were performed on the same extracts separated by polyacrylamide gel electrophoresis using sera from the same time periods. RESULTS: After 1 year on immunotherapy, the patient's allergic rhinitis symptoms resolved, and he was able to eat fresh fruits and vegetables without reaction. Skin testing and specific IgE immunoassay demonstrated a marked reduction in sensitivity to not only the pollens but the foods as well. Immunoblots revealed that the intensity of IgE binding to most components of the extracts, some common to pollens and foods, declined during immunotherapy. CONCLUSIONS: These results support the notion that oral allergy syndrome is due to cross-reacting allergens in foods and pollens and may be amenable to treatment with pollen immunotherapy.

Pasteurella multocida from canine and feline teeth, with a case report of glossitis calcinosa in a dog caused by P. multocida.

A case of glossitis calcinosa in a dog caused by Pasteurella multocida is reported. Swelling of the tongue and reduced appetite were the predominant clinical symptoms. Due to latent infections with P. multocida in many species there is a risk of bitewounds being infected with this microorganism. In order to find the carrier-rate of P. multocida samples in canines, teeth and gingiva of 121 dogs and 30 cats were examined bacteriologically, revealing a carrier rates of 55% and 80% respectively. The rate is significantly higher in dogs with poor oral hygiene (calcula), and there is a tendency towards small dogs being more at risk than large dogs and male cats more than females. The isolated strains of P. multocida were most sensitive to chloramphenicol and tetracycline whereas, many were resistent to penicillin and sulfa. The theory, that this pattern should be explained by the common use of the latter drugs in veterinary practice, is not valid under Danish conditions, where chloramphenicol and tetracycline are commonly used in the small animal clinic. Accordingly suspected P. multocida infections should be treated with chloramphenicol or tetracycline, until the result of a sensitivity test is available, and not with penicillin which today is the general routine.